With a potential blockbuster drug, Cempra had high hopes. Now, it struggles at the FDA’s finish line, minus its lauded founder.

Stepping off the interstates yields lots of can’t-miss Tar Heel treasures.

Twenty-seven companies based in North Carolina each manage more than $1.5 billion in assets.

Second-home sales are sliding, but elite retreats get creative to spark new interest.

Mission Health System and Blue Cross and Blue Shield of North Carolina are fighting a historic battle.

Workforce training, research, policy and improving infrastructure make North Carolina the energy industry’s leader.

Greensboro is getting its tallest new building since 1990, reflecting renewed interest in a downtown district that has lagged the national urban-renewal trend.

Debra Plousha Moore shows what happens when women mentor other women around the world.

Small town, big company: Mt. Olive Pickle rises to the top.

Largely unnoticed, Republican lawmakers have prioritized higher spending on the state’s transportation network.

The Amazon-Whole Foods deal puts Asheville-based Earth Fare in the crosshairs of the grocery wars.

Three veterans of shopping-center developer Edens are off to a fast start creating their own $1 billion urban retail portfolio.

Financial-services companies excel on Business North Carolina’s annual list of Top 75 public companies.

A new kind of doctor’s office eliminates the insurance middleman.

Winterville is changing, but barbecue keeps a town — and pork — pure.

DealCloud helps investment bankers, lenders, chief financial officers and others involved in mergers and financial transactions stay organized.

The uptick in boat sales means marinas are investing in expansions and upgrades.

With a potential blockbuster drug, Cempra had high hopes. Now, it struggles at the FDA’s finish line, minus its lauded founder.

In March, Adrienne Cole took the helm of the Greater Raleigh Chamber of Commerce, becoming the first woman to lead the business-development group.